LIPOSOMAL FORMULATIONS

CLODRONATE SUV LIPOSOMES & CONTROL SUV LIPOSOMES:

Clodronate SUV Liposomes

Artificial spheres consisting of a single phospholipid bilayer encapsulating an aqueous PBS (phosphate buffered saline) solution containing clodronate. The Liposomal suspension has been extruded and sized to 200nm in diameter and will not tend to precipitate upon storage. The concentration of clodronate in the suspension is ca. 5 mg/ml.

Upon request, the size can be reduced to 120-150nm with an extra extrusion step.

Control SUV Liposomes

Control liposomes do not contain clodronate. Containing PBS only, they can be used for control experiments, in order to find out whether the effects observed after injection of clodronate liposomes are exclusively due to macrophage depletion. The Liposomal suspension has been extruded and sized to 200nm in diameter which makes it the preferred control for the Clodronate SUV liposomes.

Upon request, the size can be reduced to 120-150nm with an extra extrusion step.