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Life Technologies (India) Pvt Ltd. 306, Agarwal City Mall, opposite M2K Pitampura, Delhi-110034 (India) Tel # +91-11-4220-8000; 4220-8111; 4220-8222 Fax# +91-11-4220-8444, Mobile# +91-98105-21400 Email# customerservice@lifetechindia.com |
Ocular Toxicity
Life Technologies has developed specialized programs to address ocular studies focusing on drug efficacy and safety. We understand that the observation of ocular indications and effects should consider systemic routes of exposure, rather than solely relying on intravenous administration.
In Vitro Assays Conducted by Life Technologies
- Conducting OECD 491 assay with SIRC cell line for short-term exposure.
- EpiOcular™ eye irritation assay using 3D reconstructed human corneal epithelium tissue model (OECD 492)
Ocular Toxicity Assessment
- Specular microscopy for non-invasive, in vivo evaluation of the corneal endothelium
- Tonometry (IOP) evaluations
- Enhanced microscopic evaluation
- Ocular histopathology
- Quantitative autoradiography (2D and 3D)
- Detailed tissue dissections analyze ocular and systemic distribution using various techniques.
- Corneal fluorescein staining
- Schirmer tear/phenol red thread testing
- Esthesiometry
- In vitro corneal opacity and permeability
Life Technologies Preclinical Examination and Service for Ocular Toxicity
- Electroretinography (ISCEV, custom protocols, and VEP)
- SD-OCT enables anterior and posterior imaging and retinal layer segmentation.
- Pachymetry (corneal thickness)
- Digital fundus photography/video
- CSLO provides 3D images using infrared and tomography modes.
- Fundus autofluorescence
- Fluorescein angiography (FA)
- Indocyanine green angiography (ICG)
- Vitrectomy
- Aqueous/vitreous humor collections and biomarker quantification
- Slit-lamp bio microscopy
- Indirect and direct ophthalmoscopy
- Gonioscopy
- Streak retinoscopy
- Draize test
- Ocular reflexes