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Life Technologies (India) Pvt Ltd. 306, Agarwal City Mall, opposite M2K Pitampura, Delhi-110034 (India) Tel # +91-11-4220-8000; 4220-8111; 4220-8222 Fax# +91-11-4220-8444, Mobile# +91-98105-21400 Email# customerservice@lifetechindia.com |
Dermal Toxicity
Acute toxicity testing for skin irritation, corrosion, and sensitization are also necessary for the research and discovery of new drugs, and our skilled experts construct models for these studies. The epiderm and episkin testing procedure is checked using 3D skin models, and skin corrosion classifications are made possible by chemicoassay. To detect corrosion, irritation, and sensitization, silica models are employed. whether using in vitro testing, topically administered substances, or both.
The use of a sensitizing agent with host proteins to check for hypersensitivity responses caused by sensitizers as they bind as small molecules to the proteins. They become immunogenic and make the immune system work, which makes the spot inflamed. Using in vitro tests makes it possible to take a tiered approach and screen. We also offer a comprehensive testing plan that includes different skin tests.
Life Technologies's In Vitro Skin Assays
- In vitro irritation using 3D reconstructed human epidermis models (OECD 439)
- In vitro skin corrosion using 3D reconstructed human epidermis models (OECD 431)
- Phototoxicity assay using BALB/c-3T3 cells
- Skin sensitization assay using KeratinoSens cell line (OECD 442D)
- Skin sensitization by directing peptide reactivity assay (OECD 442C)
Markers For Sensitization for Derma Toxicity.
Drug development businesses use the first test results from HaCaT cells because they are so good. The whole process is done by the HaCaT cell line, which has been made to live forever. With this process, the amount of epidermal compound exposure is well understood. It lets the person making the drug save money and try multiple compounds in a human keratinocyte model before testing them on a primary cell model or in an animal study.