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Life Technologies (India) Pvt Ltd. 306, Agarwal City Mall, opposite M2K Pitampura, Delhi-110034 (India) Tel # +91-11-4220-8000; 4220-8111; 4220-8222 Fax# +91-11-4220-8444, Mobile# +91-98105-21400 Email# customerservice@lifetechindia.com |
Colon Diseases
Life Technologies offers various in vitro models designed to mimic the intestinal barrier and aid in pharmaceutical screening for Inflammatory Bowel Disease (IBD). Our comprehensive approach encompasses conventional 2D synthetic and cell-based systems, 3D models replicating key features of the intestinal architecture, and micro-physiological systems (MPSs) that simulate the dynamic stimuli encountered by cells in their native microenvironment. By utilizing these models, we provide a deep understanding of how the human intestine functions and offer insights into the pathophysiology of IBD, including Crohn's disease and ulcerative colitis.
Inflammatory bowel disease (IBD)/CROHN’S
Discovery Services:
- Cytotoxicity and proliferation assays
- Pro and anti-inflammatory marker studies
- Gut microbiome analysis by NGS
- Host–microbiome interactions and pathways
- Measurement of ALP, ZO-1, MMP2, MMP9, MUC2, MUC5AC, and ADAMTS1
Available Models:
- Human colon cell lines: CaCO2, HCT116, HT-29 etc.
- Co culture of CaCO2 and HT29-MTX cells
- 3D organoids of intestinal epithelial, enteroendocrine goblet cells and immune cells
Techniques Used: Flow Cytometry, Confocal/Fluorescence Microscopy (Multi-colour Immunofluorescence), ELISA (Fluorimetry/Colorimetry), RTqPCR, WB.