Catalog_No | Drug Name/ Product Name |
CAS | Product Line | Target | Path | Area | Citation |
HY-13948 | Angiotensin II human | 4474-91-3 | Peptides | Angiotensin Receptor; Apoptosis | Apoptosis; GPCR/G Protein | Cardiovascular Disease; Endocrinology; Cancer | [A1]
[A2] [A3] [A4] [A5] |
HY-P0035 | Insulin (human) | 11061-68-0 | Peptides | Insulin Receptor | Protein Tyrosine Kinase/RTK | Metabolic Disease; Endocrinology |
[B1]
[B2] |
HY-W002300 | Boc-L-Valine | 13734-41-3 | Peptides | Amino Acid Derivatives | [C1] | ||
HY-W009970 | Ethyl 2-(benzylamino)acetate | 6436-90-4 | Peptides | Others | [D1] | ||
HY-13948 | Angiotensin II human | 4474-91-3 | Peptides | Angiotensin Receptor; Apoptosis | Apoptosis; GPCR/G Protein | Cardiovascular Disease; Endocrinology; Cancer | [E1]
[E2] [E3] [E4] [E5] |
HY-P1731B | Tirzepatide (hydrochloride) | Peptides | GCGR | GPCR/G Protein | Metabolic Disease | [F1] |
[A1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.
[A2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.
[A3]. Hu C, et al. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50(5):952-957.
[A4]. Nabah YN, et al. Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Circulation. 2004;110(23):3581-3586.
[A5]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90."
[B1]. Bell GI, et al. Sequence of the human insulin gene. Nature. 1980 Mar 6;284(5751):26-32.
[B2]. Tseng CH, et al. Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes. BMC Cancer. 2015 Nov 4;15:846.
[C1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
[D1]. Jason Mccartney, et al. Modulators of cystic fibrosis transmembrane conductance regulator. Patent WO2022076625A1.
[E1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.
[E2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.
[E3]. Hu C, et al. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50(5):952-957.
[E4]. Nabah YN, et al. Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Circulation. 2004;110(23):3581-3586.
[E5]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.
[F1]. Frias JP, et al. Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial. Lancet. 2018 Nov 17;392(10160):2180-2193.
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