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Stem_Cell_Signaling_Compound_Library
Cat. No.: HY-L017
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.
MCE owns a unique collection of 1463 compounds that can be used for stem cell regulatory and signaling pathway research.
MCE Stem Cell Signaling Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1426 compounds supplied in 10 mM solution, 34 compounds supplied in 2 mM solution and 3 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Size (Pre-dissolved Solution or Solid)
- 30 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 50 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution) - 100 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution) - 2 × 100 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution)
Publications Citing Use of MCE Compound Libraries
• Elife. 2021 Sep 29;10:e65811. [Abstract]
• BMC Cancer. 2019 Oct 16;19(1):959. [Abstract]
• Nat Med. 2017 Apr 7;23(4):405-408. [Abstract]
• Chem Rev. 2020 Oct 28;120(20):11616-11650. [Abstract]
• Circulation. 2022 Apr 12;145(15):1154-1168. [Abstract]
• J Med Virol. 2021 Jun 1. [Abstract]
• Nat Commun. 2018 Apr 26;9(1):1677. [Abstract]
• Nat Commun. 2020 Sep 4;11(1):4417. [Abstract]
• Acta Pharm Sin B. 2021 Jan;11(1):143-155. [Abstract]
• EMBO Mol Med. 2021 Dec 20;e14608. [Abstract]
• J Biomed Sci. 2018 Aug 2;25(1):60. [Abstract]
• Cell Syst. 2018 Apr 25;6(4):424-443.e7. [Abstract]
• Cell Rep. 2017 Jul 25;20(4):999-1015. [Abstract]
• J Cheminform. 2018 Jul 31;10(1):34. [Abstract]
• J Med Chem. 2018 Jan 11;61(1):360-371. [Abstract]
• J Invest Dermatol. 2021 Sep 14;S0022-202X(21)01672-9. [Abstract]
• Life Sci. 2020 Oct 1;258:118228. [Abstract]
• Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]
• Epigenetics Chromatin. 2020 Aug 3;13(1):31. [Abstract]
• Sci Rep. 2017 Oct 16;7(1):12881. [Abstract]
• ACS Chem Biol. 2016 Dec 16;11(12):3400-3411. [Abstract]
• ACS Chem Biol. 2016 May 20;11(5):1245-54. [Abstract]
• Biol Reprod. 2017 Nov 1;97(5):671-687. [Abstract]
• SLAS Discov. 2020 Sep;25(8):895-905. [Abstract]
• Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
• In Vitro Cell Dev Biol Anim. 2016 Apr;52(4):488-96. [Abstract]
• Acta Med Iran. 2017 Mar;55(3):200-208. [Abstract]
| Description & Advantages | ||||||
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• A unique collection of 1463 small molecule inhibitors with biological activity used for stem cell regulatory and signaling pathway research. • Targets such as GSK-3, Hedgehog, Notch, JAK, ROCK, Wnt, γ-secretase, Casein Kinase, etc. • A powerful tool for researching the mechanism behind stem cells, regenerative therapy, drug screening based on tumor stem cells, as well as other pharmaceutical and biological applications. • Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA. • Structurally diverse, medicinally active, and cell permeable. • Rich documentation with structure, IC50, and customer reviews. • NMR and HPLC validated to ensure the highest purity. • All compounds are in stock and continuously updated. |
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| Product Details | ||||||
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• Formulation:A collection of 1463 stem cell signaling related compounds supplied as pre-dissolved Solutions or Solid • Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty. 384-well plate: the first two columns and the last two columns are left empty. Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know. • Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode • Storage:-80°C • Shipping:Blue ice |
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| Composition | ||||||
| Stem Cell Signaling Compound Library (Source: MedChem Express) | ||||||
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| Documentation | ||||||