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Natural_Product_Library
Cat. No.: HY-L021
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.
Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.
MCE provides a unique collection of 3948 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).
MCE Natural Product Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 3827 compounds supplied in 10 mM solution, 82 compounds supplied in 2 mM solution and 39 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Size (Pre-dissolved Solution or Solid)
- 30 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 50 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution) - 100 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution) - 2 × 100 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution)
Publications Citing Use of MCE Compound Libraries
• Signal Transduct Target Ther. 2022 Aug 15;7(1):288. [Abstract]
• Acta Pharm Sin B. 2021 May 13.
• J Exp Clin Cancer Res. 2023 Feb 9;42(1):45. [Abstract]
• Cancer Immunol Res. 2023 Mar 15;CIR-22-0483. [Abstract]
• Pharmacol Res. 2022 Jun 2;106279. [Abstract]
• Cell Biosci. 2021 Feb 28;11(1):45. [Abstract]
• Free Radic Biol Med. 2021 Nov 5;S0891-5849(21)00790-5. [Abstract]
• Free Radic Biol Med. 2023 Apr 10;S0891-5849(23)00373-8. [Abstract]
• Phytother Res. 2023 Apr 24. [Abstract]
• Int J Mol Sci. 2023, 24(3), 1900.
• J Chem Inf Model. 2017 Sep 25;57(9):2099-2111. [Abstract]
• Front Cell Infect Microbiol. 07 April 2021.
• Viruses. 2019 Sep 5;11(9):826. [Abstract]
• Molecules. 2022, 27(22), 7774
• J King Saud Univ Sci. 23 November 2021, 101728.
• Pharmacology. 2020;105(5-6):311-319. [Abstract]
• Nutraceuticals. 2022, 2(2), 71-90.
• Research Square Preprint. 2021 Sep.
• Nat Med. 2017 Apr 7;23(4):405-408. [Abstract]
• Chem Rev. 2020 Oct 28;120(20):11616-11650. [Abstract]
• Circulation. 2022 Apr 12;145(15):1154-1168. [Abstract]
• J Med Virol. 2021 Jun 1. [Abstract]
• Nat Commun. 2018 Apr 26;9(1):1677. [Abstract]
• Nat Commun. 2020 Sep 4;11(1):4417. [Abstract]
| Description & Advantages | ||||||
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• A unique collection of 3948 natural products for high throughput screening (HTS) and high content screening (HCS). • The compounds in the library contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. • A useful tool for drug discovery as an important source of lead compounds. • Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA. • Structurally diverse, bioactive, and cell permeable. • More detailed compound information with structure, IC50, and brief introduction. • NMR and HPLC validated ensure high purity. • All compounds are in stock and continuously updated. |
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| Product Details | ||||||
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• Formulation:A collection of 3948 natural products supplied as pre-dissolved Solutions or Solid • Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty. 384-well plate: the first two columns and the last two columns are left empty. Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know. • Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode • Storage:-80°C • Shipping:Blue ice |
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| Composition | ||||||
| Natural Product Library (Source: MedChem Express) | ||||||
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