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Kinase Inhibitor Library
Cat. No.: HY-L009
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.
Kinase inhibitor library designed by MCE contains 2698 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.
MCE MCE Kinase Inhibitor Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 2623 compounds supplied in 10 mM solution, 71 compounds supplied in 2 mM solution and 4 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Size (Pre-dissolved Solution or Solid)
- 30 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 50 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 100 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 2 100 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution)
Publications Citing Use of MCE Compound Libraries
• Nat Commun. 2018 Apr 3;9(1):1303. [Abstract]
• Sci Adv. 2023 Mar;9(9):eade3760. [Abstract]
• EMBO J. 2021 Apr 28;e106771. [Abstract]
• Plant Biotechnol J. 2022 Sep 19. [Abstract]
• Cancer Immunol Res. 2023 Mar 15;CIR-22-0483. [Abstract]
• Cancers. 2020 Apr 7;12(4):901. [Abstract]
• Int J Mol Sci. 2022 Sep 16;23(18):10819. [Abstract]
• Sci Rep. 2022 Oct 25;12(1):17877. [Abstract]
• Nat Med. 2017 Apr 7;23(4):405-408. [Abstract]
• Chem Rev. 2020 Oct 28;120(20):11616-11650. [Abstract]
• Circulation. 2022 Apr 12;145(15):1154-1168. [Abstract]
• J Med Virol. 2021 Jun 1. [Abstract]
• Acta Pharm Sin B. 2021 Jan;11(1):143-155. [Abstract]
• EMBO Mol Med. 2021 Dec 20;e14608. [Abstract]
• J Biomed Sci. 2018 Aug 2;25(1):60. [Abstract]
• Cell Syst. 2018 Apr 25;6(4):424-443.e7. [Abstract]
• Cell Rep. 2017 Jul 25;20(4):999-1015. [Abstract]
• J Cheminform. 2018 Jul 31;10(1):34. [Abstract]
• J Med Chem. 2018 Jan 11;61(1):360-371. [Abstract]
• J Invest Dermatol. 2021 Sep 14;S0022-202X(21)01672-9. [Abstract]
• Life Sci. 2020 Oct 1;258:118228. [Abstract]
• Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]
• Epigenetics Chromatin. 2020 Aug 3;13(1):31. [Abstract]
• Sci Rep. 2017 Oct 16;7(1):12881. [Abstract]
| Description & Advantages | ||||||
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• A unique collection of 2698 phosphorylation kinase inhibitors/regulators for high throughput screening (HTS) and high content screening (HCS). • The library contains compounds targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase). • Kinase inhibitors have played an increasingly prominent role in the treatment of cancer and other diseases. • Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA. • Structurally diverse, medicinally active, and cell permeable. • Rich documentation with structure, IC50, and customer reviews. • NMR and HPLC validated to ensure high purity. • All compounds are in stock and continuously updated. |
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| Product Details | ||||||
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• Formulation:A collection of 2698 kinase inhibitors/regulators supplied as pre-dissolved Solutions or Solid Solution: 2623 compounds supplied in 10 mM solution, 71 compounds supplied in 2 mM solution, 4 compounds supplied in 3 mg/mL solution. • Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty. 384-well plate: the first two columns and the last two columns are left empty. Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know. • Container96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode • Storage:-80°C • Shipping:Blue ice |
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| Composition | ||||||
| Natural Product-like Compound Library (Source: MedChem Express) | ||||||
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