Cat. No.: HY-L005

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 1037 epigenetics-related compounds that can be used in the research of the related diseases.

MCE Epigenetics Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1023 compounds supplied in 10 mM solution, 11 compounds supplied in 2 mM solution and 3 compounds supplied in 3 mg/mL solution.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

Size (Pre-dissolved Solution or Solid)

  • 50 μL/well Solution
    (10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution)
  • 100 μL/well Solution
    (10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution)
  • 2 × 100 μL/well Solution
    (10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution)

Publications Citing Use of MCE Compound Libraries

Description & Advantages

•   A unique collection of 1037 small molecule modulators with biological activity used for epigenetics research and associated assays.

•   The library contains epigenetics-related compounds targeting HDAC, Histone Demethylase, Histone Acetyltransferase (HAT), DNA Methyltransferase (DNMT), Epigenetic Reader Domain, MicroRNA, etc.

•   A valuable tool for chemical genomics, epigenetic target identification in pharmacogenomics, and other biological applications.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure the highest purity.

•   All compounds are in stock and continuously updated.

Product Details

• Formulation:A collection of 1037 epigenetics related compounds supplied as pre-dissolved Solutions or Solid
Solution: 1023 compounds supplied in 10 mM solution, 11 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

• Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.

384-well plate: the first two columns and the last two columns are left empty.

Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

• Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

• Storage:-80°C

• Shipping:Blue ice

Bioactive Compound Library(Source: MedChem Express)

Life Technologies (India) Pvt Ltd. 

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