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Life Technologies (India) Pvt Ltd. 306, Agarwal City Mall, opposite M2K Pitampura, Delhi-110034 (India) Tel # +91-11-4220-8000; 4220-8111; 4220-8222 Fax# +91-11-4220-8444, Mobile# +91-98105-21400 Email# [email protected] |
Drug Repurposing Compound Library
Cat. No.: HY-L035
New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved and clinical drugs, especially after phase I drugs, have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.
MCE Drug Repurposing Compound Library contains 4271 approved drugs and passing phase Ⅰclinical drugs, which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties.
MCE Drug Repurposing Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 4136 compounds supplied in 10 mM solution, 101 compounds supplied in 2 mM solution and 34 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Size (Pre-dissolved Solution or Solid)
- 30 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 50 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 100 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 2 × 100 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution)
Publications Citing Use of MCE Compound Libraries
• Cell Stem Cell. 2022 Apr 7;29(4):545-558.e13. [Abstract]
• Int J Mol Sci. 2019 Jul 17;20(14):3504. [Abstract]
• Pharmaceuticals. 2021, 14(7), 604.
• Pharmaceuticals. 2022 Mar 24;15(4):396. [Abstract]
• Biomedicines. 2022 Mar 10;10(3):641. [Abstract]
• Biomedicines. 2022, 10(3), 641.
• BMC Bioinformatics. 2021 Jan 7;22(1):17. [Abstract]
• Nat Med. 2017 Apr 7;23(4):405-408. [Abstract]
• Chem Rev. 2020 Oct 28;120(20):11616-11650. [Abstract]
• Circulation. 2022 Apr 12;145(15):1154-1168. [Abstract]
• Nat Commun. 2020 Sep 4;11(1):4417. [Abstract]
• Acta Pharm Sin B. 2021 Jan;11(1):143-155. [Abstract]
• EMBO Mol Med. 2021 Dec 20;e14608. [Abstract]
• J Biomed Sci. 2018 Aug 2;25(1):60. [Abstract]
• Cell Syst. 2018 Apr 25;6(4):424-443.e7. [Abstract]
• Cell Rep. 2017 Jul 25;20(4):999-1015. [Abstract]
• J Cheminform. 2018 Jul 31;10(1):34. [Abstract]
• J Med Chem. 2018 Jan 11;61(1):360-371. [Abstract]
• J Invest Dermatol. 2021 Sep 14;S0022-202X(21)01672-9. [Abstract]
• Life Sci. 2020 Oct 1;258:118228. [Abstract]
• Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]
• Epigenetics Chromatin. 2020 Aug 3;13(1):31. [Abstract]
• Sci Rep. 2017 Oct 16;7(1):12881. [Abstract]
| Description & Advantages | ||||||
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• A unique collection of 4271 compounds that have been marketed or successfully passed through Phases I for high throughput screening (HTS) and high content screening (HCS). • Used in the research of oncology, cardiology, anti-inflammatory, immunology, dermatology, endocrinology, neurology, and more. • A useful tool for drug repurposing. • Structurally diverse, bioactive, and cell permeable. • More detailed compound information with structure, IC50, and brief introduction. • NMR and HPLC validated ensure high purity. • All compounds are in stock and continuously updated. |
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| Product Details | ||||||
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• Formulation:A collection of 4271 bioactive compounds supplied as pre-dissolved Solutions or Solid • Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty. 384-well plate: the first two columns and the last two columns are left empty. Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know. • Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode • Storage:-80°C • Shipping:Blue ice |
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