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Antibiotics Library
Cat. No.: HY-L067
Antibiotics are types of antimicrobial products used for the treatment and prevention of bacterial infections. Antibiotics can kill or inhibit bacterial growth. Although the target of an antibiotic is bacteria, some antibiotics also attack fungi and protozoans. However, antibiotics rarely have an effect on viruses. The major mechanism underlying antibiotics is the inhibition or regulation of enzymes involved in cell wall biosynthesis, nucleic acid metabolism and repair, protein synthesis, or disruption of membrane structure. Many of these cellular functions targeted by antibiotics are most active in multiplying cells. Since there is often overlap in these functions between prokaryotic bacterial cells and eukaryotic mammalian cells, it is not surprising that some antibiotics have also been found to be useful as anticancer agents.
MCE supplies a unique collection of 569 antibiotics, including penicillins, cephalosporins, tetracyclines, macrolides, etc. MCE Antibiotics Library is a useful tool for anti-bacterial or anti-cancer drugs discovery.
MCE Antibiotics Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 544 compounds supplied in 10 mM solution, 15 compounds supplied in 2 mM solution and 10 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Size (Pre-dissolved Solution or Solid)
- 30 μL/well Solution
(10 mM and 2 mM Pre-dissolved Solution) - 50 μL/well Solution
(10 mM and 2 mM Pre-dissolved Solution) - 100 μL/well Solution
(10 mM and 2 mM Pre-dissolved Solution) - 2 × 100 μL/well Solution
(10 mM and 2 mM Pre-dissolved Solution)
Publications Citing Use of MCE Compound Libraries
• Nat Med. 2017 Apr 7;23(4):405-408. [Abstract]
• Chem Rev. 2020 Oct 28;120(20):11616-11650. [Abstract]
• Circulation. 2022 Apr 12;145(15):1154-1168. [Abstract]
• J Med Virol. 2021 Jun 1. [Abstract]
• Nat Commun. 2018 Apr 26;9(1):1677. [Abstract]
• Nat Commun. 2020 Sep 4;11(1):4417. [Abstract]
• Acta Pharm Sin B. 2021 Jan;11(1):143-155. [Abstract]
• EMBO Mol Med. 2021 Dec 20;e14608. [Abstract]
• J Biomed Sci. 2018 Aug 2;25(1):60. [Abstract]
• Cell Syst. 2018 Apr 25;6(4):424-443.e7. [Abstract]
• Cell Rep. 2017 Jul 25;20(4):999-1015. [Abstract]
• J Cheminform. 2018 Jul 31;10(1):34. [Abstract]
• J Med Chem. 2018 Jan 11;61(1):360-371. [Abstract]
• J Invest Dermatol. 2021 Sep 14;S0022-202X(21)01672-9. [Abstract]
• Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]
• Epigenetics Chromatin. 2020 Aug 3;13(1):31. [Abstract]
• Sci Rep. 2017 Oct 16;7(1):12881. [Abstract]
• ACS Chem Biol. 2016 Dec 16;11(12):3400-3411. [Abstract]
• ACS Chem Biol. 2016 May 20;11(5):1245-54. [Abstract]
• Biol Reprod. 2017 Nov 1;97(5):671-687. [Abstract]
• SLAS Discov. 2020 Sep;25(8):895-905. [Abstract]
• Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
• In Vitro Cell Dev Biol Anim. 2016 Apr;52(4):488-96. [Abstract]
• Acta Med Iran. 2017 Mar;55(3):200-208. [Abstract]
• bioRxiv. 2021 Jun 15;2021.05.15.444128. [Abstract]
• Chem Biol. 2015 Aug 20;22(8):1144-55. [Abstract]
• Faculty of Medicine, Medicum. University of Helsinki. 2017 Dec.
| Description & Advantages | ||||||
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• A unique collection of 569 antibiotics for high throughput screening (HTS) and high content screening (HCS). • The antibiotics in the library contain penicillins, cephalosporins, tetracyclines, macrolides, etc. • A useful tool for the discovery of anti-bacterial and anti-cancer drugs. • Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA. • Structurally diverse, medicinally active, and cell permeable. • Detailed compound information with structure, IC50, and brief introduction. • Validated NMR and HPLC to ensure high purity and quality. • All compounds are in stock and continuously updated. |
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| Product Details | ||||||
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• Formulation:p>A collection of 569 antibiotics supplied as pre-dissolved Solutions or Solid • Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty. 384-well plate: the first two columns and the last two columns are left empty. Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know. • Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode • Storage:-80°C • Shipping:Blue ice |
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| Composition | ||||||
| Antibiotics Library (Source: MedChem Express) | ||||||
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