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Apoptosis_Compound_Library
Cat. No.: HY-L003
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.
MCE designs a unique collection of 1905 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.
MCE Apoptosis Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1855 compounds supplied in 10 mM solution, 44 compounds supplied in 2 mM solution and 6 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Size (Pre-dissolved Solution or Solid)
- 30 μL/well Solution
(10 mM , 2 mM and 3 mg/mL Pre-dissolved Solution) - 50 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution) - 100 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution) - 2 × 100 μL/well Solution
(10 mM, 2 mM and 3 mg/mL Pre-dissolved Solution)
Publications Citing Use of MCE Compound Libraries
• Cell Mol Life Sci. 2022 Jun 4;79(6):340. [Abstract]
• J Biotechnol. 2022 Aug 10;S0168-1656(22)00179-1. [Abstract]
• Nat Med. 2017 Apr 7;23(4):405-408. [Abstract]
• Chem Rev. 2020 Oct 28;120(20):11616-11650. [Abstract]
• Circulation. 2022 Apr 12;145(15):1154-1168. [Abstract]
• J Med Virol. 2021 Jun 1. [Abstract]
• Nat Commun. 2018 Apr 26;9(1):1677. [Abstract]
• Nat Commun. 2020 Sep 4;11(1):4417. [Abstract]
• Acta Pharm Sin B. 2021 Jan;11(1):143-155. [Abstract]
• EMBO Mol Med. 2021 Dec 20;e14608. [Abstract]
• J Biomed Sci. 2018 Aug 2;25(1):60. [Abstract]
• J Cheminform. 2018 Jul 31;10(1):34. [Abstract]
• J Med Chem. 2018 Jan 11;61(1):360-371. [Abstract]
• J Invest Dermatol. 2021 Sep 14;S0022-202X(21)01672-9. [Abstract]
• Life Sci. 2020 Oct 1;258:118228. [Abstract]
• Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]
• Epigenetics Chromatin. 2020 Aug 3;13(1):31. [Abstract]
• Sci Rep. 2017 Oct 16;7(1):12881. [Abstract]
• ACS Chem Biol. 2016 Dec 16;11(12):3400-3411. [Abstract]
• ACS Chem Biol. 2016 May 20;11(5):1245-54. [Abstract]
• Biol Reprod. 2017 Nov 1;97(5):671-687. [Abstract]
• SLAS Discov. 2020 Sep;25(8):895-905. [Abstract]
• Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
• In Vitro Cell Dev Biol Anim. 2016 Apr;52(4):488-96. [Abstract]
| Description & Advantages | ||||||
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• A unique collection of 1905 small molecules used for survival, proliferation and apoptosis research. • Targets such as Bcl-2 Family, Caspase, DAPK, IAP, MDM2/p53, PKD, Survivin, etc. • Bioactivity and safety confirmed by preclinical research and clinical trials, some compounds have been approved by FDA. • A useful tool to study apoptosis-involved regulation and diseases such as cancer, aging, neurodegenerative disease, and more. • Structurally diverse, medicinally active, and cell permeable. • More detailed compound information with structure, IC50, and other chemical & biological data. • NMR and HPLC validated to ensure high purity and quality. • All compounds are in stock and continuously updated. |
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| Product Details | ||||||
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• Formulation:A collection of 1905 apoptosis related compounds supplied as pre-dissolved Solutions or Solid • Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty. 384-well plate: the first two columns and the last two columns are left empty. Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know. • Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode • Storage:-80°C • Shipping:Blue ice |
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| Composition | ||||||
| Anti-Infection Compound Library (Source: MedChem Express) | ||||||
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