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Introduction:
An antibiotic used with PhytoSelect Medium (P6800) for the selection of Ralstonia solanacearum and other plant pathogens.
Min. Potency = >6000 u/mg
1 MU = 1 Million Units
1G = >6 MU
5G = >30 MU
25G = >150 MU
P6809 Polymyxin B Sulfate
| Synonyms: | Polymixin, Polymixin B |
| CAS: | 1405-20-5 |
| Formula: | C55H96N16O13 • 2H2SO4 |
| Mol. Weight: | 1385.61 |
Properties
| Form: | Powder |
| Appearance: | White to Off-White Powder |
| Application: | Phytopathology, Seed Testing, Microbiology |
| Solubility: | Soluble in Water |
| Storage Temp: | 2-8°C |
| Typical Working Concentration: | Varies with applications, should be determined by end user. |
Application Notes
Active against gram negative bacteria. Acts against microorganisms by binding to and interfering with the permeability of the cytoplasmic membrane.
Can be used with PhytoSelect Basal Medium (Prod # P6800) and additional antibiotics to select for Acidovorax avenae and Ralstonia solanacearum (Kawanishi 2011). See table on next page for media formulation details.
References
Kawanishi T, T. Shiraishi, Y. Okano, K. Sugawara, M. Hashimoto, K Maejima, K Komatsu, S Kakizawa, Y Yamaji, H Hamamoto, K Oshima, S Namba (2011) New Detection Systems of Bacteria Using Highly Selective Media Designed by SMART: Selective Medium-Design Algorithm Restricted by Two Constraints. PLoS ONE Volume 6, Issue 1.
Morrison DC, Jacobs DM (1976) Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry.13(10):813-8.
Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. Pubmed Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. Pubmed